2-Methylindole, also known as o-toluidine, is an organic compound with the chemical formula C9H9N. It is a pale yellow to brown liquid with a strong, unpleasant odor. In this article, we will discuss the introduction, uses, synthetic route, and wholesale price of 2-methylindole in China.
## Introduction
2-Methylindole is a heterocyclic compound that belongs to the indole family. It is commonly used as a building block for the synthesis of pharmaceuticals, agrochemicals, and dyes. It is also known to be a key component in the aroma of roasted coffee and tobacco.
## Uses
2-Methylindole has a wide range of applications. It is mainly used in the production of dyes, especially indigo dyes. It is also used in the synthesis of pharmaceuticals, such as antihistamines and anti-inflammatory drugs. Additionally, it is commonly used as a flavoring agent in the food industry due to its roasted coffee and tobacco aroma.
## Synthetic Route
2-Methylindole is synthesized through several methods. One of the most common methods is the Fischer indole synthesis. In this method, o-toluidine is reacted with a strong acid, such as sulfuric acid, and an aldehyde or ketone in the presence of heat. The reaction produces 2-methylindole as the final product.
Another method is the Pictet-Spengler reaction. In this method, a tryptamine derivative is reacted with an aldehyde or ketone in the presence of an acid catalyst. The reaction produces 2-methylindole as a minor product.
## Wholesale Price in China
The wholesale price of 2-methylindole in China varies depending on the supplier and the quantity purchased. As of 2021, the average wholesale price for 2-methylindole is around 100 USD per kilogram. However, the price can range from 80 USD to 120 USD per kilogram depending on the quantity purchased and the supplier.
In conclusion, 2-methylindole is an important organic compound with various applications in the pharmaceutical, dye, and food industries. Its synthetic route involves various methods, with the Fischer indole synthesis and the Pictet-Spengler reaction being the most common. The wholesale price of 2-methylindole in China is around 100 USD per kilogram, making it an affordable option for many industries.
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